TABLE 2.

Effects of p11C, C-M epitope point mutations on SIV viabilitya

VirusGag expressionVirion release (%)Virus production (%)Core stability (%)Infectivity
Wild type+++100100100+
C46A+++84102126+
T47A++97784+
P48A+932648
Y49A+++825911
D50A+843613
I51A+102177
N52A+136210
Q53A+++10198139+
M54A+76175
Y49Q++972642
I51L+++936135
Q53T+++11220124+
  • a Comparisons to the wild-type virus were made by normalizing the values in the assays and establishing the values for the wild-type virus as 100%.