TABLE 1.

Effects of lysosomotropic agents on HSV entry

VirusCell line% β-Galactosidase expression with:
NH4CI (50 mM)Monensin (30 μM)
HSV-1 strain KOS-rid1Vero119.4 ± 19.193.8 ± 3.0
CHO expressing nectin-11.0 ± 0.90
CHO expressing nectin-200
HeLa9.9 ± 3.06.6 ± 1.2
HSV-1 strain KOSCHO expressing HveA4.0 ± 0.70
HSV-1 strain MPCHO expressing nectin-112.5 ± 3.99.7 ± 1.9
HSV-2 strain GCHO expressing nectin-1010.5 ± 3.2
CHO expressing HveA1.7 ± 1.27.0 ± 2.7