TABLE 2.

Phenotypes of rescued viruses containing point mutations in PB2a

VirusPlaque sizeVirus yieldProtein synthesiscRNAvRNAPrimary transcription
Wild type++++NormalNormalNormalNormalNormal
F130Y+++++IncreasedNormalIncreasedIncreasedNormal
R142A+DelayedDelayedDelayedDelayedNormal
R142K++DelayedDelayedDelayedDelayedNormal
  • a See Table 1, footnote a.