TABLE 3.

HPV11 L1 interactions with L2 proteins from other papillomaviruses

VirusHostLocation of infection (level of risk)aSupergroupbL1/L2 ratiocInteraction with HPV11 L1d
HPV11HumanGenital tract (low)A10>1:1Strong
HPV6bHumanGenital tract (low)A10>1:1Strong
HPV16HumanGenital tract (high)A9>1:1Strong
HPV33HumanGenital tract (moderate)A9>1:1Strong
HPV1aHumanSkinE1NDUndetectable
HPV5HumanSkinB1<1:1Weak
HPV12HumanSkinB1<1:1Weak
COPV1DogOralE<1:1Weak
BPV1CowSkinC1NDUndetectable
  • a Risk of genital tract isolates for progression to cervical carcinoma.

  • b Supergroup designation is that defined in Human Papillomaviruses (1) based on a phylogenetic tree computed from a consensus primer region of L1.

  • c Relative amounts of L1 to the GST=L2 fusion proteins indicated with aterisks on Fig. 6A were determined by densitometric analysis of Coomassie blue-stained SDS-polyacrylamide gels.

  • d Strength of interaction with L1 is based on the ability to detect L1 by immunoblot analysis, as well as the relative amounts of L1 and L2. ND, not determined.