TABLE 2.

Sequence analysis of replicons extracted from parental and resistant clones

CloneMutation(s)
NS3 (protease)NS3 (helicase)NS5A
HBI10AE176GK@67
R10D168YE176GP264LK@67
R12D168VE176GG394SI446VK@67E438K
R7aP67SD168AE176KR512K
  • a Only the sequence of the NS3-4A region was determined for this clone.