TABLE 4.

Peptide-binding capacities of common HLA-DR molecules

ProteinAmino acid positionsSequenceIC50aNo. of molecules bound (out of 8)
DRB1*0101DRB1*0401DRB1*0405DRB1*0701DRB1*1101DRB1*1302DRB1*1501DRB5*0101
p1737-51ASRELERFAVNPGLL285.39904311161,83410563,6736
p1741-51LERFAVNPGLL3,18519,26323,8801,4077,115596,82225,8321
p1742-58ERFAVNPGLLETSEGCR961,2221133,0954631616,2987,3934
p1777-94SLYNTVATLYCVHQRIEV27961110783,841921,7017816
p24133-150WIILGLNKIVRMYSPTSI0.621.43.3108191.80.311028
p24133-144WIILGLNKIVRM125,3538,92013,6341070.71171715
p24135-145ILGLNKIVRMY3,2926531,2335,5362,0745.46.51,6153
p24139-150NKIVRMYSPTSI0.484.46.6482461560.847608
p24164-181YVDRFYKTLRAEQASQEV6.0153523110197176328
p24167-178RFYKTLRAEQAS3.8700770900790>50,0002178037
p24168-180FYKTLRAEQASQE0.3713891,8876542,686651886
p24168-179FYKTLRAEQASQ0.42363,4293,94424>50,0001,352764
p24169-177YKTLRAEQA7133,147>50,00030,66626,791>50,000>50,00024,7121
p1566-81RQANFLGKIWPSHKGR7584467327,1876294541.3487
Nef176-193PEKEVLVWKFDSRLAFHH3.47381,050971445120.0801777
Nef184-199KFDSRLAFHHMARELH2693,0873,864704728,6001241025
  • a An IC50 of ≤1,000 is considered significant (underlined). Boldface indicates peptides tested in comprehensive screening experiments and recognized by at least 25% of individuals.