Overview of a selection of activating and inhibitory NK cell receptors in humans and/or mice and their corresponding ligandsa

Receptor typeHumanMouse
ActivatingDNAM-1 (CD226)PVR (Necl5, CD155), nectin 2 (CD112)DNAM-1 (CD226)PVR (Necl5, CD155), nectin 2 (CD112)
CRTAM (CD355)Necl-2CRTAM (CD355)Necl-2
NKG2DMICA/B, ULBP1 to -6NKG2DRae-1, MULT-1, H60
NKp46 (CD335)Viral HA, and HN, CFP (properdin)NKp46Viral HA, CFP (properdin)
NKp44 (CD336)Viral HA and HN, PCNA,b MLL5, PDGF-DD
NKp30 (CD337)B7-H6, BAT3, HCMV pp65c
CD16Fc portions of IgGCD16Fc portions of IgG
2B4 (CD244)CD482B4 (CD244)CD48
Activating KIRHLA-A11,-Bw4, -C(Asn77-Lys80)
CD94-NKG2C/E/HHLA-E (for CD94-NKG2C)KLRD1-KLRC2/3 (CD94-NKG2C/E)Qa-1(b)
PILR betaCD99
Tactile (CD96)CD155 (Necl5, CD155)Tactile (CD96)PVR (Necl5, CD155), nectin 1 (CD111)
InhibitoryInhibitory KIRMHC class I polymorphismsInhibitory Ly49MHC class I
TIGITPVR (Necl5, CD155), nectin 2 (CD112)TIGITPVR (Necl5, CD155), nectin 2 (CD112)
LIR-1 (ILT-2/CD85j/LILRB1)HLA (α3), HCMV UL18
IRp60 (CD300a)PS, PECD300aPS, PE
  • a Abbreviations: DNAM-1, DNAX accessory molecule 1; PVR, poliovirus receptor; Necl, nectin-like molecules; CRTAM, class I-restricted T cell-associated molecule; MHC, major histocompatibility complex; MIC, MHC class I chain-related protein; ULBP, UL16 binding proteins; Rae-1, retinoic acid early inducible 1; MULT-1, mouse UL-16-binding protein-like transcript 1; H60, minor histocompatibility protein 60; HCMV, human cytomegalovirus; BAT3, human leukocyte antigen (HLA)-B-associated transcript 3; AICL, activation-induced C-type lectin; KACL, keratinocyte-associated C-type lectin; PILR, paired immunoglobulin-like type 2 receptor; KIR, killer-cell immunoglobulin-like receptor; CRTAM, class I-restricted T cell-associated molecule; HA, hemagglutinin; HN, hemagglutinin-neuraminidase; IgG, immunoglobulin G; LLT1, lectin-like transcript 1; TIGIT,T cell immunoglobulin and immunoreceptor tyrosine-based activation motif (ITIM) domain; PS, phosphatidylserine; PE, phosphatidylethanolamine; CEACAM, carcinoembryonic antigen-related cell adhesion molecules; CFP, complement factor P; PDGF, platelet-derived growth factor; IRp60, inhibitory receptor protein 60; TIM-3, T cell immunoglobulin domain and mucin domain 3; PCNA, proliferating cell nuclear antigen; MLL5, mixed lineage leukemia 5; LIR-1, leukocyte immunoglobulin-like receptor 1; HAVCR2, hepatitis A virus cellular receptor 2; LILRB1, leukocyte immunoglobulin-like receptor, subfamily B member 1; ILT-2, immunoglobulin-like transcript 2.

  • b Triggers inhibitory signaling via NKp44.

  • c Interferes with the activating signaling of NKp30.