TABLE 1.

Susceptibility of cells to HCV pseudotype infection

Cell lineCell typeHuman CD81 expressionaInfectivity (RLU, 103) of pseudotypes expressing:
No EnvVSV GSF162H E1E2Con1 E1E2
Hos.CD4.R5Human osteosarcoma24.50.1950.4120.00.10.1
Huh-7Human hepatoma48.00.14,986.90.868.658.3
Huh-7.5Human hepatoma81.30.15,469.30.189.363.2
HepG2Human hepatoma1.90.1890.00.90.10.1
PLC/PR5Human hepatoma108.00.13,553.30.19.47.5
HepHHuman liver67.50.1218.70.10.10.1
HH29Human liver2.20.13,031.70.10.10.1
Hep3BHuman liver49.40.75,123.60.1120.389.5
SK Hep1Human liver67.90.23,812.30.10.10.2
Fet Hep1.3Human liver99.40.22,869.50.10.10.2
Hepa1-6Mouse liverNA0.1410.70.20.10.1
H2-35Mouse liverNA0.1232.10.20.20.1
AML 12Mouse liverNA0.1332.60.10.10.1
FT0-2BRat liverNA0.1109.10.10.10.1
PBMCHuman peripheral blood, restingNT0.10.10.10.10.1
PBMCHuman peripheral blood, phytohemagglutinin activatedNT0.10.966.30.10.1
MT-2Human T lymphoid95.60.1913.10.10.10.1
Molt 4Human T lymphoid67.30.23.90.10.10.1
Hut-78Human T lymphoid171.50.12.60.10.10.1
DaudiHuman B cell257.30.1589.30.10.10.1
HeLaHuman epithelial114.40.161.30.10.10.1
293-THuman embryonal kidney189.40.11,300.10.10.10.1
SW13Human colorectal adenocarcinoma76.40.1559.20.20.10.1
Caco-2Human colon adenocarcinoma45.90.1250.30.10.10.1
HT-29Human fibrosarcomaNT0.11,156.80.10.10.1
  • a Median fluorescence intensity, in relative fluorescence units. NA, not applicable; NT, not tested.