TABLE 3.

Functional avidity for CD8 T-cell epitopes tested

Functional avidity (1/2max response [nM]) (range)CD8 T-cell epitopeHLA restric- tionna
High: (1-10 nM)
    3.5 (1.1-5.0)SL9 (SLYNTVATL)A23
    2.4 (1.1-4.0)QW9 (QASQEVKNW)B53, B582
    6.5 (6.0-7.0)KF11 (KAFSPEVIPMF)B571
Intermediate: (10-100 nM)
    32.5 (25.0-40.0)KF11 (KAFSPEVIPMF)B571
    42 (27-67)EI8 (EIYKRWII)B82
    13DI8 (DIYKRWII)B81
    18.5 (18.0-19.0)GY9 (GLNKIVRMY)B151
Low: (>100 nM)
    430RL11 (RDYVDRFYKTL)B441
    1,530 (440-2,600)AW11 (AEQASQEVKNW)B441
  • a n, number of subjects recognizing each epitope.