TABLE 1.

Nucleotide and amino acid mutations found in 293Rep replicons relative to the Con1 replicon sequence

ProteinMutationPresence of mutation in replicona
ntaaS22.3p98293Rep5S22.3p79293Rep17
NS2G2784AA815TXX
T3004CI888TXXXX
T3134GX
NS3C3459TL1040FX
C3535TA1065VX
T3650CX
T3881CX
C4028TX
C4043TXXXX
A4143GM1268VX
A4154GX
C4172TX
T4394GX
T4592CX
C4685TXX
A5019GS1560GXXXX
NS4AC5442TL1701FX
NS4BT5489CX
A5646GI1769VXX
T5681CX
A5730GI1797VXX
C5774TX
NS5AA6334GK1998RX
G6465CG2042RXXXX
G6618AV2093IXX
T6805CL2155PX
G6956AX
A7075GE2245GX
T7106CXX
C7314TP2325SXX
T7347CS2336PXX
A7349GXXXX
G7368AA2343TX
T7513CL2391PX
T7554AW2405RX
T7557CS2406PX
A7565GX
NS5BA7653CT2438PX
A7733GX
C7767TX
A8348GX
G8441AXX
T8447CX
C8603TX
C8860TA2840VXX
T8999CXXXX
A9131GXX
T9225GS2962VX
C9226TS2962V
C9368YX
  • a X, mutation is present.