TABLE 1.

Heterogeneity of the amino acid sequences between vaccine DNA plasmids or recombinant proteins and the inoculum J4 sequences

Sequences comparedHeterogeneity with indicated inoculum J4 sequencea
Core (191 aa)bE1 (192 aa)E2 (363 aa)NS3 (631 aa)
%No. of heterologous aa/total no.%No. of heterologous aa/total no.%No. of heterologous aa/total no.%No. of heterologous aa/total no.
DNA vector products2.14/1912.65/194c12.642/334d9.459/630
Proteins2.14/1915.98/13513.541/3044.714/299
  • a Results are percentages of heterogeneity relative to the inoculum sequence

  • b Numbers in parentheses indicate the total length of the protein sequence, and numbers of heterologous amino acids out of the total number used in the vaccines.

  • c DNA plasmid also codes for part of the C terminus of core as a signal sequence for E1.

  • d DNA plasmid also codes for part of the C terminus of E1 as a signal sequence for E2.