Table 3.

TTV and HCV dynamics in doubly infected patients treated with IFN

VirusEffectiveness of drug ɛ (mean ± SE)Viral parameter (mean ± SE)
Delay of drug response (t0 [days])Clearance rate (c [days−1])Virion half-life (t1/2[days])3-aMinimal input and clearance of plasma virions/day (1010)3-b
TTV0.94 ± 0.0022.07 ± 0.0042.5 ± 3.10.27 ± 0.313.8 ± 0.6
HCV0.85 ± 0.002<15.0 ± 4.10.14 ± 0.032.7 ± 0.4
  • F3-a Calculated by the equationt 1/2 = ln (2)/c.

  • F3-b Calculated by the equation P= cV 0, assuming that plasma and extracellular fluids were 3.0 × 103 ml in total and in equilibrium. In this equation P represents daily production of virions in plasma.