Table 2.

TTV detection and loads in the PBMC and plasma at selected times of IFN treatment

Day of treatmentNo. of patients tested2-aTTV DNA
PBMCPlasma
No. of patients positiveLog10 copies/μg of total DNA (mean ± SE)2-bNo. of patients positiveLog10 copies/ml (mean ± SE)2-b
0885.8 ± 0.586.2 ± 0.4
1885.9 ± 0.686.1 ± 0.3
2885.3 ± 0.686.5 ± 0.2
3554.9 ± 0.6* 55.2 ± 0.5*
7885.2 ± 0.685.3 ± 0.4*
30774.1 ± 0.5* 54.2 ± 0.6**
90753.6 ± 0.6** 34.1 ± 0.6**
  • F2-a Not all samples were available for all patients at all times.

  • F2-b TTV loads below detection sensitivity were arbitrarily scored as 2 and 3 log10 copies/μg of total DNA or per ml of plasma, respectively. * and **, significantly different from day 0 at P < 0.05 and P < 0.01 , respectively (Student's t test).