Table 5.

Genes modulated similarly by HCMV and UV-HCMV

GeneNuc IDaHCMV fold changebUV-HCMV fold changeb
2′-5′oligoadenylate synthetase-like AJ225089 57.1, 26.174.7, 65.1
Activating transcription factor 3 (ATF3) L19871 6.5, 8.647.3, 47.9
Acute myeloid leukemia protein X90976 −3.4, −4.1−3.7, −3.8
ADP-ribosylation factor-like 7 AB016811 ∼−19.0, ∼−16.2−3.3, −3.5
Adrenomedullin D14874 −11.8, −11.5−11, −12.1
AML1 mRNA for AML1b protein (alternatively spliced product) D43968 −6.1, −11.5−3.7, −3.9
Apolipoprotein AI regulatory protein (ARP-1) M64497 −5.1, −5.6−5.5, −5.5
B2-bradykinin receptor 3 X86163 −8.2, −7.9−7.7, −9.1
beta-transducin repeat containing protein Y14153 ∼5.0, ∼8.9∼5.4, ∼4.6
C2f U72514 ∼−6.9, −3.7−6.3, ∼−12.6
cAMP-responsive element modulator S68271 3.8, 4.35.3, 4.7
cdc25 homolog S78187 −3.1, −2.3−8.3, −4.6
Cdc42 effector protein 2 AF001436 −3.7, ∼−11.3∼−11.4, ∼−8.8
c-fos V01512 11.1, 8.523, 23.7
Chromosome 12 open reading frame AF052105 4.1, 4.54.4, 4.4
Cleavage stimulation factor, 3′ pre-RNA, subunit 1, 50 kDa L02547 ∼6.1, −5.4∼−12.7, −7.9
Core-binding factor, runt domain, alpha subunit 2; cyclin D-related D43638 −6, −6.9−3.2, −4
Cyclin E2 AF091433 4.6, ∼6.6∼4.7, ∼6.6
Cyclin-dependent kinase inhibitor 1B (p27, Kip1) AI304854 ∼−16.0, −10.8−5.6, −8.4
Cyclooxygenase 2 U04636 5.7, 3.925.6, 23.3
DKFZP564B0769 protein AL080186 ∼−8.9, ∼−5.7∼−9.0, ∼−6.4
DKFZP586K1520 protein AL050153 −4.1, −4.5∼−12.4, ∼−13.5
DNA sequence from clone 1175I6 on chromosome 20 AL049538 −3.2, −3−3.1, −3.2
Dual-specificity phosphatase 10 AB026436 ∼−8.9, ∼−11.9∼−12.6, −3.9
EGR alpha S81439 −6.5, −3.6−3.8, −4.5
ESTs H94842 −9, −4.6−5.5, −7.2
Fucose-1-phosphate guanylyltransferase AF017445 −3.8, −7.5−3.4, −3.1
Gamma-interferon-inducible early response gene (homology to platelet proteins) X02530 ∼3.0, ∼7.4∼199.1, ∼179.1
gas1 L13698 −27.1, −37.7−24, −19.4
Growth differentiation factor 5 (cartilage-derived morphogenetic protein 1) X80915 ∼−24.0, ∼−24.0∼−19.6, ∼−25.3
GS3955 D87119 ∼−19.9, ∼−20.0−9.9, −12.6
GTP cyclohydrolase 1 (dopa-responsive dystonia) U19523 3.6, ∼7.2∼34.9, ∼29.2
homeo box A9 U41813 ∼−8.9, ∼−9.2∼−10.9, ∼−11.9
Homo sapiens cDNA FLJ13555 fis, clone PLACE1007677 AL080210 ∼−7.5, ∼−5.4∼−6.7, ∼−7.0
Homo sapiens cDNA, 5′ end N36638 −7.3, −8.9−6.4, −7.1
Homo sapiens cig5 mRNA,  partial sequence AF026941 ∼12.7, ∼18.9∼326.2, ∼290.8
Homo sapiens mRNA; cDNA DKFZp564G103 AL049268 ∼−5.7, ∼−5.0∼−6.1, ∼−6.5
hSIAH1 U76247 −3, −4.1−3.4, −3.7
hTCF-4 Y11306 ∼−22.5, ∼−13.2∼−18.3, ∼−17.2
Hypothetical protein AA522530 −4.1, −3.6−9.8, −3.7
Hypothetical protein LOC57187 AA928996 ∼−9.5, ∼−6.5∼−4.2, ∼−5.1
Hypothetical protein FLB6421 AI133727 6, 5.49.4, 9
Hypothetical protein FLJ10262 AA115140 −5.2, −6.3−5.7, −5
Inhibitor of DNA binding 2, dominant-negative helix-loop-helix protein D13891 −3.9, −3−10.2, −6.6
Interferon-induced protein with tetratricopeptide repeats 4 AF026939 11.3, 8.88.6, 7.4
Interleukin 11 X58377 ∼41.1, ∼53.5∼133.9, ∼113.1
ISG-54K gene (interferon-stimulated gene) M14660 32.2, 16.711, 10.6
KIAA0112 protein; homolog of yeast ribosome biogenesis regulatory protein RRS1 D25218 ∼−8.3, −5.3∼−12.7, ∼−11.4
KIAA0671 gene product AB014571 −10.1, −8.9−10.8, −9.6
KIAA1010 protein AB023227 −3.4, −6.5−11.1, −7.9
KIAA1116 protein AB029039 −3.9, −3.3−4.4, −4.6
KIAA1288 protein AL096842 ∼−5.9, ∼−3.2∼−7.2, ∼−4.5
Monoclonal antibody 21 (Caenorhabditis elegans)-like 1 U38810 −13.9, −30.5−14.7, −9.7
Meis1 (mouse) homolog U85707 −5.5, ∼−21.8−6.5, −5
Mitogen-induced nuclear orphan receptor (MINOR) U12767 8, 13.37.5, 5.7
MN1 X82209 −21, ∼−34.0∼−31.6, ∼−31.4
Myxovirus resistance 1, homolog of murine (interferon-inducible protein p78) M33882 5.2, 3.920.2, 17.4
Novel human gene mapping to chomosome 13, similar to rat RhoGAP AL049801 −3.5, ∼−15.9−4.9, −4
Nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 4 L41066 ∼−18.6, ∼−14.3∼−8.2, ∼−10.7
Nuclear receptor subfamily 4, group A, member 2 X75918 ∼8.4, ∼9.9∼9.5, ∼10.5
Nuclear receptor subfamily 4, group A, member 3 U12767 ∼23.3, ∼41.5∼29.8, ∼19.0
Phorbol-12-myristate-13-acetate-induced protein 1 D90070 9.3, 10.830.7, 25.7
Phosphodiesterase 4B L20971 −11.2, −18.8−3.4, −4.4
Pleckstrin homology, Sec7 and coiled/coil domains 1 (cytohesin 1) M85169 7.7, 4.27.2, 6.7
Polymerase (DNA directed), gamma 2, accessory subunit U94703 4.6, ∼24.3∼7.6, ∼6.6
Protein phosphatase 1 (PPP1R5) Y18207 −7.6, −6.2−6.1, −5.3
RAN-binding protein 6 AF039023 ∼−3.8, −3.4−3.2, −3.9
ras homolog gene family, member E S82240 −5.9, −5.8−3.4, −3.6
ras inhibitor L36463 −3.5, −5.4−3.2, −3.6
RIP protein kinase U50062 3, 38.5, 7.3
runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) D43969 ∼−39.3, ∼−42.2∼−41.6, ∼−43.1
slug (chicken homolog), zinc finger protein U69196 −11, ∼−19.5−13.6, −9.2
Solute carrier family 7 M80244 4.5, 3.74, 4.3
Stromal cell-derived factor 1 L36033 −4.2, −4.5−6.3, −9.7
Thyroid receptor interactor (TRIP14) L40387 4.1, 7.461.8, 53.8
TR3 orphan receptor L13740 6.3, 13.733.9, 26.9
Transcription factor 21 AF047419 −3.9, ∼−23.0−3.2, −4
v-myc avian myelocytomatosis viral oncogene homolog V00568 ∼−12.9, ∼−9.8∼−12.9, −6.4
wee1+ (S. pombe) homolog X62048 −5.3, −5.3−4.3, −3.5
zinc finger protein 183 (RING finger, C3HC4 type) X98253 ∼−3.8, ∼−5.8∼−7.9, ∼−7.5
zinc finger protein 217 AF041259 ∼−27.9, ∼−41.2−8, −6.6
  • a Nuc ID, nucleotide sequence identification or sequence accession number.

  • b Two fold change values were determined in independent experiments. A ∼ symbol in front of a fold change value indicates that the transcript was scored as absent in either the baseline on experimental sample and that the fold change was then calculated using the background noise value as the intensity for that comparison. The complete data set with difference calls can be accessed at http://www.molbio.princeton.edu/labs/shenk/browneetal2001/.