Table 3.

HHV-6 variant-dependent changes in gene expressiona

Z ratioGene productDescriptionFunction(s)
HHV-6A/ controlHHV-6B/ controlHHV-6B/ HHV-6A
−0.701.672.37MAPK4Mitogen-activated protein kinase 4Mitogen-activated signaling
−1.60−0.011.59PIGAPhosphatidylinositol glycanPhosphatidyl signaling
−0.620.931.55PLAURPlasminogen activator, urokinase receptorPlasminogen and urokinase activity
−0.880.661.54LTBRLymphotoxin beta receptorTNF-mediated proinflammation
−0.311.221.53TNFRSF5Tumor necrosis factor receptor superfamilyTNF-mediated proinflammation
−1.190.341.53CD9CD9 antigenCell adhesion and migration
−1.57−0.071.50PLCG2Phospholipase C, gamma 2IP3 and intracellular calcium regulation
0.131.591.46NFICnuclear factor I/CCCAAT-binding transcription factor
−0.970.491.46JUNB junB proto-oncogene productJunB signaling
−0.730.711.44CD59CD59 antigenT-cell lymphocyte activation
−0.500.931.43NFATC1Nuclear factor of activated T-cellsT-cell transcription
− binding growth factor 8
0.181.511.33CD28CD28Adhesion molecule
−1.000.331.33JUND junD gene productJunD signaling
  • a The Z ratios shown are averages from two independent experiments performed in duplicate. Column 3 (HHV-6B/HHV-6A) reports the Z ratio difference in gene expression between SupT1 cells infected with variant B and those infected with variant A. The data were sorted to show high levels of gene expression in SupT1 cells infected with variant B. Columns HHV-6A/control and HHV-6B/control report Z ratio changes in gene expression in SupT1 cells infected with GS and Z29, respectively. Genes with a variance between experiments of greater than 0.2 were not analyzed.