Table 4.

HIV-1 neutralization assays using IgG 4E10 against a range of isolates from different subtypes

IsolateSubtypeIgG 4E10 concna:
50%90%
92RW009A0.94.7
92RW026A0.712
DJ259A3.516
JR-FLB9.2, 2515, >25
SF2B38>50
DH123B>50>50
HC4B>50>50
2044B>50>50
2076 cl.3 B2>50
NL4-3B>50>50
89.6 B>25>25
MNB5>50
HxBc2B0.1510
94ZW109C2.0, >506.7, >50
94ZW106C7.242
DJ258C2.06.6
ZAM20C7.9>50
DU151C3.934
92BR025 C10b
92UG035 D20
UG270D>50>50
92UG024 D>50>50
CM235E5.2, 7.511.4, 25
92TH001E2.78.2
BZ162F4.42.1
R1F0.35.1
RU570G0.357.6
G3G0.21.3
  • a 50% and 90% refer to the concentration of MAb (micrograms per milliliter) required for 50 or 90% inhibition of maximum p24 levels. Underlined values were determined in experiments using protocol B (see Materials and Methods); all other values were determined using protocol A. Asterisks indicate that the assay was performed only once for that isolate.

  • b  —, not done.