Table 1.

Influence of methyl-β-cyclodextrin on polyomavirus and SV40 infectivitya

Methyl-β-cyclodextrin concn (mM)% Infected cellsb
PolyomavirusSV40, in CV-1 cells
NIH 3T6 cellsNMuMG cells
AvgRelative to controlAvgRelative to controlAvgRelative to control
043.09100.0048.63100.0062.11100.00
124.9757.9523.9949.3344.4471.55
56.5715.257.0014.3921.3034.29
7.56.4815.046.4513.2620.6533.25
  • a Infected cells were visualized by staining with antibodies against the VP1 antigen of polyomavirus or SV40.

  • b Avg, average percent infected cells from 10 optical fields. Relative to control, infected cells as a percentage of the number of infected cells present in the non-inhibitor-treated control sample.