Table 1.

Clinical history and neuropathology of study subjectsa

PatientRisk factorbLast CD4 count (cells/μl)Antiretroviral(s)Clinical dementiaHIV-1 encephalitisGiant cellscHIV-1 isolation from brain
MACS1MH2NoneYesSevere++++
MACS2MH52AZTYesModerate++
MACS3MH95NoneYesModerate++
MACS4MH8NoneNoNone
MACS5MH14AZTYesNone
MACS6MH3IndinavirYesMild+
MACS7MH44AZTNoNone
MACS8MH36NAd NoNone
MACS9MH4NoneNoNone
MACS10MH70NoneNoNone
MACS11MH7D4Te NoNone
MACS12MH149NoneYesNone
UK1IVDU87ddc (1 mo)YesModerate+++
UK2HET297NoneNoMild+
UK3IVDU137AZT, ddI (6 wk)YesSevere++
UK4MH8D4T (1 mo)NoMild++
CB1MH10ddI (prior AZT)YesSevereNA+
CB3MH5ddI (prior AZT and ddC)YesSevereNA+
  • a Tissue samples were collected at autopsy from 18 patients who died of AIDS. The presence of clinical dementia and HIV-1 encephalitis was determined by the clinical history and neuropathological examination at the time of autopsy. Brain tissue samples were collected from frontal lobe (MACS and CB patients), or frontal lobe and basal ganglia (UK patients).

  • b MH male homosexual; IVDU, intravenous drug user; HET, heterosexual transmission; mo, months; wk, weeks; N/A, not available.

  • c Frequency of multinucleated giant cells observed in autopsy brain tissue sections. −, +, ++, and +++, none, occasional, moderate, and high, respectively.

  • d NA, not available.

  • e d4T, stavudine..