Table 1.

Study subjectsa

StatisticAge (yr)bViral load (copies/ml)bCD4 countcCD8 countc
Mean30.993,8734301,040
Median3035,082414986
Range16–52<400d–516,17512–1,11661–>2,000e
  • a Viruses were isolated in 56 of 74 subjects (75.7%). All 56 were of phenotype R5 (0 were of phenotype X4). Of 56 viral isolates, 22 (39.3%) were near full-length genome sequenced. PBMC from 46 study subjects (62.2%) were screened for HIV-1C Gag-specific CTL responses. PBMC from 48 study subjects (64.9%) were screened for HIV-1C Tat-specific CTL responses. PBMC from 47 study subjects (63.5%) were screened for HIV-1C Rev-specific CTL responses. PBMC from 45 study subjects (60.8%) were screened for HIV-1C Nef-specific CTL responses. Samples were randomly selected and screened in sets of 5 to 10 per HIV-1C protein based on PBMC availability and necessity to repeat Elispot assays.

  • b Data were available for all 74 study subjects.

  • c Data were available for 69 of 74 study subjects.

  • d Viral load of <400 copies/ml (four cases) was treated as 400 for calculation purposes.

  • e CD8 count of >2,000 (two cases) was treated as 2,000 for calculation purposes.