Table 2.

CD4+-T-cell epitopes identified in EBNA3Ca

EBNA3C aaEpitope sequenceNo. of respondersPotential restrictionb
DRDQ
66–80NRGWMQRIRRRRRRR21, 135, 6
141–155ILCFVMAARQRLQDI11, 135, 6
386–400SDDELPYIDPNMEPV61
401–415QQRPVMFVSRVPAKK111, 143, 5
546–560QKRAAPPTVSPSDTG11, 135, 6
586–600PPAAGPPAAGPRILA11, 135, 6
626–640PPVVRMFMRERQLPQ111, 143, 5
649–660PQCFWEMRAGREITQ2NoneNone
916–930PSMPFASDYSQGAFT34
961–986AQEILSDNSEISVFPK4[4][2, 3, 5]
  • a The sequence of EBNA3C is derived from the B95.8 prototype strain of EBV.

  • b Potential restriction elements were identified as described for Table 1. None, responders had no shared DR or DQ allele.