Table 3.

CD4+-T-cell epitopes identified in LMP1 and LMP2a

Antigen and aaEpitope sequenceNo. of respondersPotential restrictionb
DRDQ
LMP1
 130–144LWRLGATIWQLLAFF11, 41, 3
 212–226SGHESDSNSNEGRHH32
 340–354TDGGGGHSHDSGHGG1NDc ND
LMP2
 149–163STVVTATGLALSLLL21, 135
 169–182SSYAAAQRKLLTPV21, 135, 6
 224–243VLVMLVLLILAYRRRWRRLT2NoneNone
 385–398STEFIPNLFCMLLL1NDND
  • a The sequences of LMP1 and LMP2 are derived from the B95.8 prototype strain of EBV.

  • b Potential restriction elements were identified as described for Table 1.

  • c ND, not determined.