Table 3.

Neutralizing antibody titers (50%) in rhesus monkeys immunized with YF/DEN monovalent vaccine, WT DEN, or YF-VAX

GroupMonkeyVirus [strain] (dose, log10 PFU)b50% PRNT by postimmunization daya:
3079
1T340YF/DEN1 (4.3)8040
T791640320
T7442,5601,280
 GMT (SD)508 (1,300)254 (650)
2T747YF/DEN3 (3.6)<20<20
T38380160
T144640160
 GMT (SD)37 (348)29 (92)
3T230YF/DEN4 (3.8)10<10
T2602,5605,120
T5482,560320
 GMT (SD)403 (1,472)117 (2,868)
5T725WT DEN1 [PUO 359] (3.9)2,5605,120
T6132,5605,120
T5472,56010,240
 GMT (SD)2,560 (0)6,450 (2,956)
6T502WT DEN3 [PaH881/88] (5.2)640320
T6001,2802,560
T6021,2801,280
 GMT (SD)1,016 (369)1,016 (1,124)
7T264WT DEN4 [1228] (3.8)1,2802,560
T5291,2802,560
T42710,2402,560
 GMT (SD)2,560 (5,173)2,560 (0)
8BA29YF-VAXb(5.0)2,5601,280
V5765,1202,560
V2022,5601,280
 GMT (SD)3,225 (1,478)1,613 (739)
  • a Titers of sera on day 0 were <10 in all animals.

  • b Determined by back titration of inocula.