Table 8.

Immunogenicity of YF/DEN1-4 tetravalent vaccine in YF-immune and nonimmune rhesus monkeys

YF immuneMonkeybTiter on day 30 post-secondary immunization by:
DEN1DEN2DEN3DEN4
Yesa BA291602,56064080
V57632064032080
V20232064016080
 GMT (SD)254 (92)1,016 (1,108)350 (244)80 (0)
NoBF3332010,2402080
BF291602,5604080
BJ4316064020160
BD241606402020
BB881606404040
BG3016064016080
 GMT (SD)180 (65)1,280 (3,840)36 (55)63 (48)
Pc 0.170.600.0130.91
  • a Refer to Table 3 for PRNT against YF.

  • b The PRNT against DEN1-4 was <10 at the time of secondary immunization.

  • c Titers of sera from YF-immune monkeys were compared to those of nonimmune monkeys by t test (JPM version 4.0.2).