Table 5.

Viremiaa in rhesus monkeys after secondary immunization with YF/DEN1–4 tetravalent vaccine (total dose, 5.4 log10 PFU)

GroupMonkeyPrimary immunization [strain] (dose, log10 PFU)bNo. viremic/ no. tested (%)MeanSerotype detectede (day[s])
Peak titerc (SD)Durationd (SD)
1T340YF/DEN1 (4.3)2/3 (67)1.5 (0.2)1.0 (0)2 (2)
T7912 (2)
T744
2T747YF/DEN3 (3.6)1/3 (33)2.3 (0)5 (0)1 (1, 2), 2 (1, 3, 7, 9, 11)
T383
T144
3T230YF/DEN4 (3.8)1/3 (33)1.0 (0)3 (0)2 (2, 3, 4)
T260
T548
4T401YF/DEN1–4 (5.3 total)0/6 (0)
V744
BA28
T805
T354
T036
5T725WT DEN1 [PUO359] (3.9)0/3 (0)
T613
T547
6T502WT DEN3 [PaH881/88] (5.2)0/3 (0)
T600
T602
7T264WT DEN4 [1228] (3.8)0/3 (0)
T529
T427
  • a–d See Table 2, footnotes ato d.

  • e Determined by RT-PCR followed byHindIII digestion.