Table 1.

New trypsin cleavage sites are conserved in human and animal rotaviruses

Rotavirus strainaP typebG typeSequence at confirmed trypsin cleavage sitecSequence at putative trypsin cleavage site at amino acid 467
Amino acid 258Amino acid 582
Si/SA11 4F6[1]3 DIVVSKTSLWK RSASVRSVSST YEIAGRFSLIS
Si/SA11 cl35B[2]3 DIVISKTSLWK RGSSIRSIGSS YEIAGRFSLIS
Si/RRV5B[3]3 DIVVSKTSLWK RGASIRSVGSS YEVAGRLSLIS
Hu/RV-51B[4]2 DITISKTSLWK RSASIRSNLST YEMSGRFSLIS
Bo/UK7[5]6 DIVVSKTSLWK RSTSVRSIGST YEVAGRFSFIS
Hu/10762A[6]2 DIIISKTSLWK RSSSIKSNISS YEIAGRFSFIL
Po/OSU9[7]5 DIVVSKTSLWK RSSSIRSIGSS YEISGRFSLIS
Po/YM9[7]11 DIVVSKTSLWK RSSSIRSIGSS YEISGRLSLIS
Hu/Wa1A[8]1 DIIVSKTSLWK RNVSIRSNLSA YEISGRFSLIY
Hu/K83[9]1 DIVISKTSLWK RLTSVRSVGTI YEIAGRFSLIS
Hu/69M4[10]8 DIIVSKTSLWK RGSSIRSIGSS YEVAGRFSLIS
Bo/B2238[11]10 DIIISKASLWK RSSTLRSVNSA YEAAGRFSLIL
Eq/H-24[12]3 DIVISKTSLWK RNSSIRSVSSS YEIAGRFSLIS
Po/MDR-13[13]3/5 DIVISKASLWK RGSTIRSIGSS YEINGRFSLIS
La/ALA11[14]3 DIVVSKTSLWK RSVSVRSIGGN YEIAGRFSLIS
Ov/Lp14[15]10 DIVISKASLWK RNSSIRSIGST YEIAGRFSLIS
Mu/EB10[16]3 DIVVSKTSLWK RSNTIRSISST YELAGRFSLIS
Av/PO-13[17]7 DIVISKTSLWK RASSIRSNASV YETAGRFSLIS
Eq/L33812[18]13 DILISKASLWK RSSSIRSIGST YEIAGRFSLIS
Po/PRV 4F[19]3 DIVISKASPWK RNSSIRSNVSS YEIAGRFSLIS
Mu/EHP[20]3 DVVISKASLWK RSGSIRSISSN YEVAGRFSLIS
  • a Species of origin for rotavirus strains are indicated by the following abbreviations: Hu, human; Si, simian; Mu, murine; Ca, canine; La, lapine; Eq, equine; Po, porcine; Bo, bovine; Av, avian; Ov, ovine.

  • b Each P genotype is designated by the number in square brackets. Not all viruses in each P genotype have been characterized into a P serotype by neutralization assays.

  • c Sequences were obtained with the following Genbank accession numbers: SA11 4F, X57319 ; SA11cl3, M23188 ; RRV,J03567 ; RV-5, M32559 ; UK, M22306 ; 1076, M88480 ; OSU, X13190 ; YM,M63231 ; Wa, M96825 ; K8, D90260 ; 69M, M60600 ; B223, D13394 ; H-2, L04638 ; MDR-13, L07886 ; ALA, U62149 ; Lp14, L11599 ; EB, U08419 ; PO-13, AB009632 ; L338, D13399 ; PRV 4F, L10359 ; EHP, U08424 . The sites of cleavage are indicated in bold.