Table 1.

Vaccine-elicited CTL responsesa

Vaccination and monkeyTetramer bindingFunctional cytotoxicity (stimulated PBMC)
Fresh PBMCStimulated PBMC
Control MVA
 H5440.000
 H5470.001
 H5490.001
 H5610.000
Recombinant MVA
 T1190.51737
 H5000.4426
 H5070.23961
 H5110.8530
  • a SIV Gag p11C-specific CD8+T-cell responses as measured by tetramer staining of freshly isolated and peptide-stimulated PBMC and chromium release functional cytotoxicity assays at week 22, which is 1 week following the third immunization. The percent CD3+ CD8+ cells that bind tetramer is shown for the tetramer assays. The percent specific lysis at a 5:1 effector-to-target ratio is shown for the cytotoxicity assays.