Table 1.

Susceptibility of Tg(OvPrP4) mice to scrapie isolatesa

Isolate (amino acid change)First appearance of clinical signs (days p.i.)Death (days p.i.)Result ofb:
PrPres Western blotPrPsc immunohistochemistryVacuolization
1 (ARQ/VRQ)2643No
51228++++++Yes
19288Yes
26354++++++Yes
51404++Yes
31427+ndnd
29////
2 (ARQ/ARQ)230231+++ndnd
230231+++ndnd
231232++++++Yes
232238++ndnd
239240++++++Yes
259260+++ndnd
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  • a Seven Tg(OvPrP4) mice were inoculated with isolate 1 and seven were inoculated with isolate 2. Two noninoculated Tg(OvPrP4) mice were used as controls; no spontaneous disease appeared and no death occurred until 500 days p.i. Twenty C57BL/6 mice were inoculated with isolate 1 or 2; no disease was developed until 400 days p.i.

  • b nd, not determined (no fixed material); /, still alive; +, PrPsc present; −, no detectable PrPsc.