Table 2.

CTL responses following challengea

Vaccination and monkeyTetramer bindingFunctional cytotoxicity (stimulated PBMC)
Fresh PBMCStimulated PBMC
Control MVA
 H5440.122
 H5470.110
 H5490.71922
 H5611.7811
Recombinant MVA
 T1197.54829
 H5003.94937
 H50713.55934
 H5112.54228
  • a SIV Gag p11C-specific CD8+T-cell responses as measured by tetramer staining of freshly isolated and peptide-stimulated PBMC and chromium release functional cytotoxicity assays at day 17 after challenge. The percent CD3+ CD8+ cells that bind tetramer is shown for the tetramer assays. The percent specific lysis at a 5:1 effector-to-target ratio is shown for the cytotoxicity assays.