Table 3.

EBV latent gene expression and promoter usage in Akata and Mutu cells infected with Akata virusa

Cell line EBNA-1EBNA-2LMP1QUKY3UK
Akata 2A8b
Akata Accl-2e ++
Akata A cl-3+++
Akata A cl-4+NDf ND
Akata A cl-5++
Akata A cl-6++
Akata A cl-7e +++
Akata Bccl-1+NDND
Akata B cl-2+NDND
Akata B cl-3e ++
Akata B cl-4+++
Akata B cl-5++
Akata B cl-6+++
Akata B cl-7e +++
Mutu 9d,e
Mutu 9 C1e ++
Mutu 9 D1e ++
Mutu 9 D2+NDND
Mutu 9 D3++
Mutu 30d
Mutu 30 cl-1e ++
Mutu 30 cl-2++
Mutu 30 cl-3+NDND
  • a See Table 2, footnote a.

  • b Akata 2A8 is an EBV-negative variant of the Akata cell line.

  • c Akata A- and Akata B-infected cells represent two sets generated from different infections. Some Akata clones were EBNA-2 positive 6 weeks after infection but at 4 months did not express the protein.

  • d Mutu 9 and Mutu 30 are two EBV-negative clones derived from Mutu cells.

  • e These lines were also examined for either Qp or W/Cp usage by using additional sets of nested primers that distinguish the two transcripts.

  • f ND, not determined.