Table 2.

cII mutation spectrum in ATX and wild-type animals

Mutation typeOccurrence ina:
ATXbWTcControld
Transitions
 G/C → A/T11627
 A/T → G/C582
Transversions
 G/C → T/A448
 G/C → C/G016
 A/T → T/A991
 A/T → C/G220
Othere 116
Total isolates323150
  • a Total no. of mutants bearing the specified mutation.

  • b Mutant cII isolates from three 240-day-old DEN-treated ATX animals.

  • c Mutant cII isolates from three 240-day-old DEN-treated wild-type (WT) animals.

  • d Control, mutation spectrum of mutantlacI isolates from untreated mouse liver tissue according to the work of Ross and Leavitt (49).

  • e Included are deletions, additions, and jackpot mutations (mutations that occur early in the development of the mouse and are amplified by cellular replication).