Table 1.

Pedigreed PI and TCLA virusesa

VirusIsolate typeCoreceptor(s) usedCentral V3 loopAdaptation-associated aa changesReference(s)
168PPICCR5 and CXCR4 NIRKRIHIGPGRAFYTTG 28, 65
168CTCLACXCR4 NIRKRIHIGPGRAFYTTR V2 I166R, C2 I282N, and V3 G318R
320SIPICCR5 and CXCR4 NTRKGIHIGPGRAFYAAR 16
320SI-C3.3TCLACCR5 and CXCR4 NTRKGIRIGPGRAFYAAR V2 I166K and V3 H317R
  • a Amino acid (aa) changes in the central V3 loop of the TCLA virus are underlined.