Table 1.

Inhibition of p38MAPK decreases viral yielda

TreatmentViral yield (PFU, 107)b at:
18 h24 h28 h32 h
DMSO6.5 ± 0.312 ± 121 ± 117 ± 1
SB2035806.0 ± 0.38.0 ± 0.48.9 ± 0.47.7 ± 0.4
  • a Cells (5 × 106) were pretreated with 30 μM SB203580 or DMSO for 1 h and infected with wt HSV-1 in the continuous presence of SB203580 or DMSO.

  • b Viral yields were determined at 18, 24, 28, and 32 h postinfection. Each value represents the mean ± standard deviation from three independent experiments, and in each experiment triplicate determinations were performed.