Table 2.

Env-directed MAbsa

AntibodyTargetNominal epitopebSourceReference
50.1V3 loop ....RIHIG......... Repligen Corp.63
58.2V3 loop .......IGPGRAF.... Repligen Corp.63
59.1V3 loop ........GPGRAF.... Repligen Corp.63
257-DV3 loop ...KRIHI.......... S. Zolla-Pazner19
268-DV3 loop ......HIGPGR...... S. Zolla-Pazner19
447-52DV3 loop ........GPGR...... S. Zolla-Pazner19
IgG1b12CD4-bsD. Burton, from ARRRP5 
559-64DCD4-bsS. Zolla-Pazner25
F105CD4-bsM. Posner50
17bCD4-iSee reference 27 J. Robinson60
2F5gp41gp41...ELDKWAH. Katinger40
F240gp41gp41...aa 592–606M. Posner7 
  • a CD4-bs, CD4-binding site; CD4-i, CD4 induced; aa, amino acids; ARRRP, NIH AIDS Research and Reference Reagent Program.

  • b Nominal MAb epitopes are reported in the associated references. Central V3 loop epitopes are arrayed as in Table1.