Table 2.

Virus production in cell lines with either wild-type or mutant p53

Cell lineCells producing virus (%)a
dl309dl1520
Wild-type p53
 A5499570
 U2OS90<10
Mutant p53
 C33A9590
 H12999228
 Saos-29022
  • a Average of two independent experiments from each of which at least 200 cells were counted. Cells that were clearly infected were scored for the presence or absence of virus particles. Cells were infected with each virus at an MOI sufficient to infect at least 80% of the cells and processed 24 to 32 h postinfection for transmission electron microscopy.