Table 1.

Protection from challenge with rVV expressing HIV-1 Gag antigens following consecutive immunizations of mice with DNA and FPV expressing HIV-1 Gag

Immunization regimen vac-gag/pol titerd following challenge
Control6.8 ± 0.6
rFPVa alone6.4 ± 0.3
DNAb i.m. alone4.9 ± 0.7
DNA epidermallyc alone3.7 ± 0.6
DNA i.m. plus rFPV3.9 ± 0.7
DNA epidermally plus rFPV<2.0
  • a FPV expressing HIV-1SF2 gag and pol.

  • b pNL4.3dpol HIV-1 DNA vaccine (33).

  • c Delivered via gene gun to shaved epidermis.

  • d Titer of rVV expressing HIV-1SF2 gag and pol in ovaries. Results are log10 mean PFU ± standard error of the mean. The limit of detection is 2.0.