Table 2.

RSV-specific CTLp frequencies for MHC class I- and II-restricted lymphocytes isolated from the spleens of BALB/c mice at various time points post-i.n. infection with RSV or an HPIV3 controla

No. of days p.i.bVirusMHC classCTLp frequency rangec
3RSVI>106
3RSVII>106
4RSVI1:29,200–1:37,900
4RSVII1:71,800–1:75,700
5RSVI1:2,200–1:8,300
5RSVII1:2,300–1:12,100
7RSVI1:4,800–1:6,000
7RSVII1:5,500–1:6,300
7HPIV3I>106
10RSVI1:5,000–1:6,300
10RSVII1:2,000–1:2,900
10HPIV3I>106
12RSVI1:4,000–1:6,400
12RSVII1:2,200–1:3,300
48RSVI1:26,900–1:33,400
48RSVII1:14,200–1:21,200
  • a Three individual mice were examined at each time point for the frequencies of class I-and II-restricted CTLps, and the range of frequencies is shown.

  • b Number of days after RSV infection.

  • c The 95% confidence limits for all of the CTLp frequencies shown ranged from 710 to 1,800. The limiting-dilution protocol used 51Cr-labeled, RSV-infected target cells and uninfected target cells to determine the background. The values for uninfected targets were always >1:500,000 and are not shown. The CTLp frequency for naive animals was >1:106.