Table 1.

Virus replication in STAT1+/+ and STAT1−/− cells

CloneaWSN (PFU/ml)b
CD1 +/+ A<10
CD1 +/+ B<10
CD1 +/+ I7 × 103
B6 +/− 136 × 104
CD1 −/− 78 × 106
CD1 −/− 31 × 106
CD1 −/− I4 × 106
B6 −/− 61 × 106
  • a Independent cell lines were derived from primary MEFs from CD1 STAT1+/+ mice (clones CD1 +/+ A, CD1 +/+ B, and CD1 +/+ I), C57B6 STAT1+/− mice (clone B6 +/− 13), CD1 STAT1−/− mice (clones CD1 −/− 7, CD1 −/− 3, and CD1 −/− I), and C57B6 STAT1−/− mice (clone B6−/− 6).

  • b Cell monolayers were infected with WSN virus at an MOI of 0.001 and incubated at 37°C; 2 days p.i., virus in supernatants was quantitated by plaque assay in MDBK cells.