Table 1.

Analysis of saliva and vaginal washes obtained from mice immunized three times intranasally while anesthetized by using 5 μg of HPV16 VLPs, either with or without 5 μg of CT

Source/sampleCT adjuvant usedFinal sample dilutionAnti-HPV16 VLP IgA titersAnti-HPV16 VLP IgG titersNeutralization (%)
Vaginal wash/A+3.3 × 10−1 591197100
Vaginal wash/A+4.9 × 10−2 8830100
Vaginal wash/B+2.1 × 10−1 10327100
Vaginal wash/B+2.6 × 10−2 13346
Vaginal wash/C3 × 10−1 91691
Vaginal wash/C4.4 × 10−2 1310
Vaginal wash/D+9 × 10−2 18743
Vaginal wash/D+1 × 10−2 20.80
Vaginal wash/E1.3 × 10−1 261.322
Vaginal wash/E1.5 × 10−2 30.20
Saliva/F+9 × 10−2 16912100
Saliva/F+1 × 10−2 191.322
Saliva/G+1.1 × 10−1 898100
Saliva/G+1.2 × 10−2 100.836
Salvia/H4 × 10−2 110.40