Table 1.

Inhibitor resistance of 487-derived virusesa

Virus cloneIC50 (SD) (nM)IC90 (SD) (nM)
487WW2.4 (1.5)9 (6.6)
487WM1,502 (487)>3,125
487MM1,933 (322)>3,125
487MW6.7 (2.4)23 (12)
487Wm99 (59)448 (144)
487Mm302 (195)1,041 (359)
  • a SQV IC50s and IC90s were measured in a single-cycle resistance assay on P4 cells.