Table 3.

Genotypes of five AZT- and 3TC-resistant clones from patient samples

LAIMutation in amino acidsa
190 to 315315 to 359
G2-1bG2-3gV178aG2-2aV213b
M41LLLL
D67NNN
K70R
M184VVVVV
L210WWWWW
T215YYYY
K219EE
G196E
T200 I I
E203 K D
Q207 E AD
H208 Y
R211 K K K KK
L214 F F F FF
L228 H
V245 E M
P272 A
R277 K K N
L283 I I
R284 K K
T286 P
I293 V
E297 A
E300 DQ
K311 R R
I326V
I329V V
G333 D E
Q334 N
T338 S
F346 Y
K347 R
R356KK K
T357MM M M
G359SS S
A360T
A371VV
T376A
K388R
  • a Boldfacing indicates the amino acid substitutions in the fragment conferring dual resistance. —, wild-type sequence (relative to LAI).