Table 4.

AZT susceptibility of HIV-1 clones from clinical samples with a reversion at RT codon 333

Viral recombinant AZT IC50, μM (fold resistance)
xxLAI0.006
G2-2a0.2 (33)
G2-2a/D333G (revertant)0.03 (5)
V213b3.7 (617)
V213b/E333G (revertant)0.54 (90)
xxLAI-np/41L/184V/210W/215Y0.007 (1.2)
xxLAI-np/41L/184V/210W/215Y/333D0.046 (7.7)