Table 1.

Effects of mutations on Tva viral receptor function

ResidueMutationAP+cells/ml of virus (% of wt valuea)
D46G3.9 × 105 (71)
S2.8 × 104 (5)
I1.9 × 104 (3)
A2.6 × 103 (0.5)
Y1.5 × 102 (0.03)
C9 × 101 (0.02)
R0 (0)
E47F4.7 × 105 (85)
A3.9 × 105 (71)
S3.2 × 105 (58)
N1.6 × 105 (29)
I1.4 × 105 (25)
T7.4 × 104 (13)
H4.9 × 103 (0.9)
Y2.2 × 102 (0.04)
R1.1 × 102 (0.02)
P0 (0)
W48L2.8 × 105 (51)
I2.6 × 105 (47)
R1.7 × 105 (31)
V8.9 × 104 (16)
H2.3 × 103 (0.4)
T1.3 × 103 (0.2)
D3.4 × 102 (0.06)
N2.9 × 102 (0.05)
A2.8 × 102 (0.05)
S2.2 × 102 (0.04)
  • a The value for wt Tva was 5.5 × 105.