Table 2.

rAB chimeric RSV derivatives are attenuated in cotton rats

VirusaNo. of ratsMean virus titer (log10PFU/g of tissue)b (Duncan grouping)c in:
Nasal turbinatesLung
A2wt 66.48 ± 0.03 (A)6.08 ± 0.06 (A)
B1 wt 66.43 ± 0.05 (A)6.00 ± 0.05 (A)
rAB52.62 ± 0.11 (B)2.50 ± 0.27 (B)
rABΔSH62.38 ± 0.24 (B)2.21 ± 0.40 (B)
rABcp63.48 ± 0.56 (C)3.45 ± 0.23 (C)
rABcpΔSH63.83 ± 0.11 (C)4.00 ± 0.06 (C)
  • a Rats were administered 6.0 log10PFU intranasally under light anesthesia on day 0 and sacrificed on day 4.

  • b Virus titer was determined in the nasal turbinate and lung tissues and is shown as mean titer ± standard error.

  • c Mean virus titers were assigned to statistically similar groups (A to C) by Duncan’s multiple range test (α = 0.05). Therefore, the means in each column with different letters are significantly different.