Table 4.

Chimeric virus rABcp248/404/1030 is protective against challenge with rAB in the upper and lower respiratory tracts of chimpanzees

Immunizing virusaInoculum doseNo. of chimpanzeesMean virus titer following RSV challenge (log10PFU/ml)Peak rhinorrhea scoreb
Nasopharyngeal swabTracheal lavage
Day 3Day 5Day 7Day 3Day 5Day 7
rABcp248/404/10305.02<0.7 ± 0.001.00 ± 0.40<0.7 ± 0.00<0.7 ± 0.00<0.7 ± 0.00<0.7 ± 0.000
None43.12 ± 0.163.72 ± 0.144.28 ± 0.12<0.7 ± 0.003.78 ± 0.263.80 ± 0.153
  • a Chimpanzees were inoculated by the intranasal and intratracheal routes with the indicated amount of virus in a 1-ml dose per site. After 28 days, the chimpanzees were administered 5.0 log10PFU of rAB by the intranasal and intratracheal routes. Nasopharyngeal-swab and tracheal-lavage samples were then collected after 3, 5, and 7 days.

  • b The amount of rhinorrhea was estimated daily and assigned a score (0 to 4) that indicated extent and severity: 0, none; 1, trace; 2, mild; 3, moderate; 4, severe.