Table 2.

CNS lesion severity, macrophage infiltration, and antigen expression in SIV-infected macaques

MacaqueTime of euthanasia (days p.i.)CNS lesion severity mean scoreCNS macrophage infiltration (% area)CNS antigen expression (% area)RNA in basal ganglia (106 copy eq/μg RNA)RNA in basal ganglia (109 copy eq/g brain)
178349200.17a 000
18031871.20.270.032.81.4
18242721.83.962.6610.45.2
18033942.34.260.463.81.9
18292852.36.193.1445.522.8
17850b 852.39.463.2674.537.3
  • a The mean percent area occupied by resident macrophages in three uninfected macaques was 0.22%.

  • b Macaque 17850 died unexpectedly and thus was not perfused.