Table 3.

Profile of neutralizing activities of Fabs 201 and 202 against various SIV isolatesa

PrepnConcn (μg/ml) of Fab or IgG needed to neutralize indicated SIV strain
Homologous strainsHeterologous strains
smH4smB670smE660SIVmac251SIVmac239
Fab 2010.078<0.042ND>5.53>5.53
Fab 2020.1170.038ND>2.00>2.00
SIVIGND1.350.7840.4>50.0
  • a The concentrations of Fab or SIVIG that resulted in 50% protection of CEM×174 cells from virus-induced cell killing are shown. ND, not determined.