Table 2.

Effect of neutrophil depletion on the outcome of MVE infection in mice

Days mice treated onaNo. of miceAntibody treatmentMean days ± SD to death (P)bPercent mortality (P)c
None20None8.0 ± 1.5100 
5, 7, 920Rat serum7.5 ± 2.6 (NS)d 100 
5, 7, 920RB6-8C511.0 ± 4.0 (<0.05)45 (<0.01)
  • a Mice were infected i.p. with 104 PFU of MVE BH3479 on day 0 and received an i.p. inoculation of MAb RB6-8C5 or rat serum protein on the nominated days.

  • b Differences in average survival were analyzed by Student’s t test (16). SD, standard deviation.

  • c Differences in percent mortality were analyzed by χ2 test (16).

  • d Not significant.