Table 1.

Prototype and primary isolate strains used in this study

StrainPhenotype in MT-2 cellsMajor coreceptor useda
JRFLNSICCR5
3BSICXCR4
89.6SICCR5, CXCR4
DH12SICCR5, CXCR4
UG021SICXCR4
UG024SICXCR4
tybeb SICXCR4
  • a Determined by infection and/or fusion with QT6 and HOS cells that expressed CD4 and either CCR5 or CXCR4 (16, 18), as well as from published data (6, 10).

  • b Primary isolate generated from cerebrospinal fluid as described in Materials and Methods.