Table 2.

Characteristics of ex vivo functional CD8+repertoire against HIV and EBV in 34 HIV-1-seropositive patients

PatientHLAT-cell count (CD4/CD8)/ μl of bloodPlasma HIV RNA (copies/ml)Positive HIV peptidesPositive EBV peptides
Frequency (no. of peptides recognized by patient/total no. tested)No. of IFN-γ SFC/ 106PBMCFrequency (no. of peptides recognized by patient/total no. tested)No. of IFN-γ SFC/ 106 PBMC
TotalaMeanbRangeTotalMeanRange
Z134A24/31, B35/4027/825316,0005/112,020404100–9051/280
Z136A1/30, B8/1330/3552,503,0004/123,01575360–2,3700/20
Z130A1/32, B8/2767/1085575,0007/172,73639090–1,1720/10
Z001A2/24, B35/44117/911NDc 6/195,019836100–1,6102/4590295140–450
C03MA2/68, B15/35157/183772,0001/8500/10
Z132A3/25, B18/61163/1092316,0003/747815981–263NDND
C02MA2/−, B44/51190/85736,0001/102301/380
P08A2/28, B35/53201/82115,8002/113,4161,708416–3,0002/21969853–143
Z006A2/24, B7/37220/1180ND3/114,5511,517186–3,1631/2132
C017MA3/30, B44/65227/6531,1003/123,7351,245214–3,0000/30
P38A2/3, B7/55249/1247ND8/206,40780025–2,6102/224212138–204
Z044A2/25, B18/44291/83405/169,0711,814368–6,7001/358
Z020A2/24, B18/44293/1174ND5/152,79355828–1,7161/364
P04A1/2, B8/44303/1272440,0003/1572624280–4101/127
C014MA3/31, B38/51308/8311904/969517359–467NDND
Z129A2/11, B51/62323/98519,5007/167,5201,07470–3,0002/21,05552788–967
Z131A3/31, B14/60328/567329,0002/9536268115–421NDND
P36A2/9, B12/12329/98876,0004/134,4011,100441–1,5160/30
Z077A2/2, B7/50334/1161250,0005/106,6631,332168–3,5422/3311155148–163
Z118A24/−, B7/42346/61211,0006/84,80380017–1,7442/31557726–129
C022MA3/32, B7/62476/53727,0006/148411406–4492/21809018–162
Z067A1/2, B7/8490/5000ND8/1816,4132,051120–7,2600/30
Z112A2/−, B7/61513/NDND6/121,82530425–8702/31306550–80
Z050A1/3, B8/35545/54529,7638/195,49568610–3,0901/2555
Z028A11/23, B7/49598/98825,0007/92,28632619–8633/3862287137–432
P09A2/24, B12/17600/844112,0004/141,54238525–1,1001/3331
Z108A2/31, B44/44666/121469,0004/178,0472,011242–6,4552/31,856928195–1661
Z042A1/32, B7/8709/274731,0006/174,60276732–1,4483/356018627–460
P51A31/32, B8/27787/1952122,0009/174,58150960–1,1771/1651
Z100A2/32, B40/44858/1201ND4/1360515155–2801/3140
Z038A3/11, B35/44945/936013/1612,93399451–4,8791/31,344
Z059A11/30, B44/55952/122406/131,39123132–7552/41658215–150
P01A1/9, B8/15ND/NDND5/114,7961,128149–2,2231/1898
Z039A2/3, B27/38ND/NDND5/134,634926300–1,824NDND
  • a Sum of the numbers of SFC per 106 PBMC for all viral peptides recognized.

  • b Total intensity divided by number of peptides recognized.

  • c ND, not done.