Table 1.

Potency of inhibitors in blocking HBX transactivation correlates with potency against pure 20S proteasomes

InhibitorKi (μM) for inhibition of:
HBX function in vivoaLLVY hydrolysisb
aLLMNone>1
aLLN40–500.14
MG11510–250.021
MG1322.5–100.011
  • a Half-maximal concentrations for inhibition of HBX transactivation are derived from Fig. 4B.

  • b Ki’s for the chymotrypsin-like activity are given in reference38.